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Prospec/PRKCE Human/Protein Kinase C epsilon Human Recombinant/2µg/PKA-322-2µg
Cataloguenumber
PKA-322
Synonyms
Introduction
ProteinkinaseC(PKC)isafamilyofserine-andthreonine-specificproteinkinasesthatcanbeactivatedbycalciumandthesecondmessengerdiacylglycerol.PKCfamilymembersphosphorylateawidevarietyofproteintargetsandareknowntobeinvolvedindiversecellularsignalingpathways.PKCfamilymembersalsoserveasmajorreceptorsforphorbolesters,aclassoftumorpromoters.EachmemberofthePKCfamilyhasaspecificexpressionprofileandisbelievedtoplayadistinctroleincells.TheproteinencodedbythisgeneisoneofthePKCfamilymembers.Thiskinasehasbeenshowntobeinvolvedinmanydifferentcellularfunctions,suchasneuronchannelactivation,apoptosis,cardioprotectionfromischemia,heatshockresponse,aswellasexocytosis.Knockoutstudiesinmicesuggestthatthiskinaseisimportantforlipopolysaccharide(LPS)-mediatedsignalinginactivatedmacrophagesandmayalsoplayaroleincontrollinganxiety-likebehavior.
Description
Source
PhysicalAppearance
Formulation
UnitDefinition
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Avoidmultiplefreeze-thawcycles.
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SafetyDataSheet
SDS

