Cataloguenumber
ENZ-1093
Synonyms
Aldehydedehydrogenase,mitochondrial,AHD-M1,ALDHclass2,ALDH-E2,ALDHI.
Introduction
ALDH2ispartofthealdehydedehydrogenasefamilyofproteinswhichcatalyzethechemicaltransformationfromacetaldehydetoaceticacid.ALDH2isthesecondenzymeofthemajoroxidativepathwayofalcoholmetabolism.ALDH2has2majorliverisoforms:cytosolicandmitochondrial,whichdifferbytheirelectrophoreticmobilities,kineticproperties,andsubcellularlocalizations.NearlyallCaucasianshave2majorisozymes,whereasroughly50%ofOrientalshaveonlythecytosolicisozyme,omittingthemitochondrialisozyme.TheextremelyhigherrateofacutealcoholintoxicationwithOrientalscomparedtoCaucasiansisduetothefactoftheabsenceofmitochondrialisozyme.ALDH2hasalowKmforacetaldehydes,andislocalizedinmitochondrialmatrix.
Description
ALDH2MouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining523aminoacids(20-519)andhavingamolecularmassof56.8kDa.
ALDH2Mouseisfusedtoa23aminoacidHis-TagatN-terminusandpurifiedbyproprietarychromatographictechniques.
Source
EscherichiaColi.
PhysicalAppearance
SterileFilteredclearsolution.
Formulation
ALDH2Mouseprotein(0.5mg/ml)isformulatedinPhosphatebufferedsaline(pH7.4),20%glyceroland1mMDTT.
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.
Store,frozenat-20°Cforlongerperiodsoftime.
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan95%asdeterminedbySDS-PAGE.
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSSAAATSAVPAPNHQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEGVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS.
SafetyDataSheet
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.