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Prospec/CDK5 Human, Sf9/Cyclin-Dependent Kinase 5 Human Recombinant,Sf9/5µg/PKA-104-5µg
Cataloguenumber
PKA-104
Synonyms
CDK5,CyclinDependentKinase5,Serine/Threonine-ProteinKinasePSSALRE,TauProteinKinaseIICatalyticSubunit,CellDivisionProteinKinase5,TPKIICatalyticSubunit,Cyclin-Dependent-LikeKinase5,ProteinKinaseCDK5Splicing,EC2.7.11.22,EC2.7.11.1,EC2.7.11,PSSALRE,CDKN5,LIS7.
Introduction
Celldivisionproteinkinase5(CDK5)belongstothecyclin-dependentkinasefamily.CDK5isessentialforappropriatedevelopmentofthebrainandinordertobeactivatedCDK5mustlinktoCDK5R1orCDK5R2.CDK5doesn"tneedphosphorylationontheTloopsothatbindingwiththeactivatorisenoughtoactivatethekinase.CDK5isengagedintheprocessesofneuronalmaturationandmigration,phosphorylatingthecentralintracellularadaptorofthereelingsignalingchain.
Description
CDK5producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining298aminoacids(1-292a.a.)andhavingamolecularmassof34.1kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).CDK5isexpressedwitha6aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CDK5proteinsolution(0.25mg/ml)PhosphateBufferedSaline(pH7.4)containing40%glyceroland1mMDTT.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPPHHHHHH
SafetyDataSheet
SDS

