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Prospec/ADK Human, Active/Adenosine Kinase Human Recombinant, Active/2µg/PKA-108-2µg
Cataloguenumber
PKA-108
Synonyms
Adenosine5"-phosphotransferase,EC2.7.1.20,AK,ADK,AdenosineKinase,Adenosine5-Phosphotransferase,TesticularTissueProteinLi14,EC2.7.1.
Introduction
AdenosineKinaseisanabundantenzymeinmammaliantissueswhichcatalyzesthetransferofthegamma-phosphatefromATPtoadenosine,thusisasaregulatorofconcentrationsofbothextracellularadenosineandintracellularadeninenucleotides.Adenosinehasextensiveeffectsonthecardiovascular,nervous,respiratory,andimmunesystemsandinhibitorsoftheenzymetakeacrucialpharmacologicalpartingrowingintravascularadenosineconcentrationsandactingasanti-inflammatoryagents.
Description
ADKproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining362aminoacids(22-362a.a.)andhavingamolecularmassof40.5kDa.ADKisfusedtoa21aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TheADKproteinsolution(0.5mg/ml)contains20%glycerol,20mMTris-HClbuffer(pH8.0),1mMDTT,1mMEDTA&50mMNaCl.
StABIlity
Purity
BIOLOGicalActivity
Specificactivityis>30pmol/min/ugandisdefinedastheamountofenzymethatconvert1.0pmoleofadenosinetoAMPperminuteatpH7.5at37CinacouplesystemwithPKandLDH.
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
