Cataloguenumber
CYT-1081
Synonyms
Brain-DerivedNeurotrophicFactor,BDNF,MGC34632,Abrineurin,ANON2,BULN2.
Introduction
BDNFpromotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.BDNFisamajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsofthecns.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(ltp),long-termdepression(ltd),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.
Description
BDNFHumanRecombinantisasingle,glycosylatedpolypeptidechaincontaining116aminoacids(19-128a.a)andhavingamolecularmassof13.1kDa(calculated).BDNFisfusedtoa6a.aHistagatC-terminal.
Source
HEK293Cells.
PhysicalAppearance
Formulation
BDNFfiltered(0.4µm)andlyophilizedfrom0.5mg/mlinPBS.
Solubility
Itisrecommendedtoadddeionizedwatertoprepareaworkingstocksolutionofapproximately0.5mg/mlandletthelyophilizedpelletdissolvecompletely.
Stability
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
APMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHHHHHH.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.