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Prospec/MS4A1 Human/Membrane Spanning 4-Domains A1 Human Recombinant/5µg/PRO-2515-5µg
Cataloguenumber
PRO-2515
Synonyms
MS4A1,B1,Bp35,CD20,CVID5,LEU-16,MS4A2,S7,B-lymphocytesurfaceantigenB1,LeukocytesurfaceantigenLeu-16,Membrane-spanning4-domainssubfamilyAmember1.
Introduction
MS4A1isanactivated-glycosylatedphosphoproteinexpressedonthesurfaceofallB-cells.Theexpressionbeginsatthepro-BphaseanduntilmaturitytheconcentrationincreasesinordertoallowoptimalB-cellimmuneresponse,specificallyagainstT-independentantigens.MS4A1takespartinthemicroenvironmentalinteractionsofBcellsandalsointheregulationofB-cellactivationandproliferation.MS4A1alsoplaysaroleasacalciumchannelinthecellmembrane.
Description
MS4A1HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining97aminoacids(210-297a.a.)andhavingamolecularmassof11.1kDa(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).MS4A1isfusedwitha9aminoacidsHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Insectcells.
PhysicalAppearance
Formulation
MS4A1proteinsolution(0.5mg/ml)containsPhosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSPHHHHHH.
SafetyDataSheet
SDS