Cataloguenumber
PRO-2615
Synonyms
Complementreceptortype2,Cr2,ComplementC3dreceptor,Epstein-Barrvirusreceptor,EBVreceptor,CD21antigen,CR2,C3DR,CD21,SLEB9.
Introduction
CD21isexpressedstronglyonmatureBcells,folliculardentriticcellsandweaklyonimmaturethymocytesandTlymphocytes.InB-cellontogeny,CD21appearsafterthepre-B-stage,ismaintainedduringperipheralB-celldevelopmentandislostuponterminaldifferentiationintoplasmacells.CD21expressionisalsograduallylostafterstimulationofBcellsinvitro.CD21functionsasreceptorforC3d,C3dgandiC3bComplementcomponents,forEBVandforIFNalpha.CD21bindstoCD23andassociateswithCD19,CD81andLeu13toformalargesignal-transductioncomplexinvolvedinBcellactivation.
Description
CD21HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining959aminoacids(21-971aa)andhavingamolecularmassof105.2kDa.CD21isfusedtoan8aminoacidHis-TagatC-terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
TheCD21solution(0.5mg/ml)contains10%GlycerolandPhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRVEHHHHHH
SafetyDataSheet
SDS