Cataloguenumber
PRO-2496
Synonyms
CD163Molecule,HemoglobinScavengerReceptor,CD163Antigen,M130,ScavengerReceptorCysteine-RichType1ProteinM130,Macrophage-AssociatedAntigen,SCARI1,MM130,CD163.
Introduction
CD163isanacutephase-regulatedreceptorwhichparticipatesintheremovalandendocytosisofhemoglobin/haptoglobincomplexesbymacrophagesandthuskeepstissuesfromfreehemoglobin-mediatedoxidativedamage.FurThermore,CD163partakesintheuptakeandrecyclingofiron,throughendocytosisofhemoglobin/haptoglobinandensuingbreakdownofheme.Inaddition,CD163bindshemoglobin/haptoglobincomplexesinacalcium-dependentandpH-dependentway.CD163demonstratesgreateraffinityforcomplexesofhemoglobinandmultimerichaptoglobinofHP-1FphenotypethanforcomplexesofhemoglobinanddimerichaptoglobinofHP-1Sphenotype.Moreover,CD163stimulatesacascadeofintracellularsignalswhichinvolvestyrosinekinase-dependentcalciumrecruitment,inositoltriphosphateformationandsecretionofIL-6&CSF-1.
Description
CD163producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining1015aminoacids(42-1050a.a.)andhavingamolecularmassof109.8kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately100kDa).CD163isexpressedwithan6aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD163proteinsolution(0.5mg/ml)containsphosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
SSLGGTDKELRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQGWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASLCPSEQVASVICSGNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGWGQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVVCRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGHSECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSHHHHHH
SafetyDataSheet
SDS