Cataloguenumber
PRO-2525
Synonyms
CD52Molecule,HumanEpididymis-SpecificProtein5,CD52Antigen,EpididymalSecretoryProteinE5,CambridgePathology1Antigen,CDW52,He5,EpididymisSecretorySpermBindingProteinLi171mP,CDW52Antigen,CD52Antigen,HEL-S-171mP,EDDM5,CDw52,HE5.
Introduction
CD52isasmallGPI(glycosylphosphatidylinositol)anchoredglycoproteinwhichistiedtothecellsurfacewithaGPIlinkage.CD52inducesimmunesuppressionbycomplement-meditatedcelllysis.Moreover,CD52isexpressedonlymphocytes,eosinophils,monocytes-deriveddendriticcells,monocytes,aswellasneutrophils,howevernotonthestemcellsfromwhichtheselymphocyteswerederived.FurThermore,CD52isasignificantgoalfortherapeuticinterventionsintendedforleukocytedepletioninpost-transplantimmunosuppression&hematologicalmalignancies.
Description
CD52producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining251aminoacids(25-36a.a.)andhavingamolecularmassof28.2kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).CD52isexpressedwitha239aminoacidhIgG-His-tagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD52proteinsolution(0.5mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
GQNDTSQTSSPSLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
