Cataloguenumber
PRO-2540
Synonyms
CD44Molecule(IndianBloodGroup),HematopoieticCellE-AndL-SelectinLigand,GP90LymphocyteHoming/AdhesionReceptor,ChondroitinSulfateProteoglycan8,ExtracellularMatrixReceptorIII,HeparanSulfateProteoglycan,PhagocyticGlycoprotein1,HyaluronateReceptor,HermesAntigen,ECMR-III,HUTCH-I,Epican,CDW44,MDU2,MDU3,MIC4,LHR,CD44Antigen(HomingFunctionAndIndianBloodGroupSystem),HomingFunctionAndIndianBloodGroupSystem,CellSurfaceGlycoproteinCD44,PhagocyticGlycoproteinI,SolubleCD44,CSPG8,HCELL,PGP-1,PGP-I,MC56,Pgp1,IN,CD44.
Introduction
CD44isacell-surfaceglycoproteinthatplaysaroleincell-cellinteractions,celladhesionandmigration.CD44isareceptorforhyaluronicacidandalsointeractswithotherligands,suchasosteopontin,collagens,andmatrixmetalloproteinases.CD44participatesinawidevarietyofcellularfunctionssuchaslymphocyteactivation,recirculationandhoming,hematopoiesis,andtumormetastasis.
Description
CD44producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(21-220a.a.)andfusedtoa239aahIgG-His-tagatC-terminuscontainingatotalof439aminoacidsandhavingamolecularmassof49kDa.CD44showsmultiplebandsbetween57-70kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD44proteinsolution(0.25mg/ml)contains10%glycerol&Phosphatebufferedsaline(pH7.4).
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
QIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
