Cataloguenumber
PRO-2616
Synonyms
CD276antigen,Cd276,6030411F23Rik,AU016588,B7h3,B7RP-2,B7homolog3,B7-H3.
Introduction
CD276,belongstotheB7familyofimmunoregulatorytransmembraneglycoproteinsexpressedbyTcells.CD276isacostimulatorymoleculeforTcellactivationinadditiontoIFN-gammaproduction.FurThermore,CD276upregulatesBRCC3expression,preventingDNAdefectscausedby5-Fu.CD276iscorrelatedwithTNMstageofNSCLCandactasapotentialbioMarkerforNSCLC-derivedMPEs.CD276inhibitsnatural-killermediatedcelllysisintumorcells,andactasamarkerfordetectionofneuroblastomacells.CD276isimplicatedinthedevelopmentofacuteaswellaschronictransplantrejectionandintheregulationoflymphocyticactivityatmucosalsurfaces.Inaddition,CD276providestheplacenta&fetusaproperimmunologicalenvironmentduringthecourseofpregnancy.
Description
CD276producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining226aminoacids(29-248a.a.)andhavingamolecularmassof24.7kDa.CD276isfusedtoa6aminoacidHis-TagatC-terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD276proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)containing10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
VEVQVSEDPVVALVDTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYSNRTALFPDLLVQGNASLRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKDLRPGNMVTITCSSYQGYPEAEVFWKDGQGVPLTGNVTTSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPLTFPPEAHHHHHH
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.