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Prospec/FCGR3B-Human/CD16b-Human-recombination/2µ;g/PRO-2486-2和181;G
Cataloguenumber
PRO-2486
Synonyms
FcFragmentOfIgGReceptorIIIb,FcFragmentOfIgG,LowAffinityIIIb,Receptor(CD16b),FcGammaReceptorIIIb,IgGFcReceptorIII-1,Fc-GammaRIII-Beta,Fc-GammaRIIIb,FCRIIIb,FCR-10,FCRIII,FCGR3,CD16b,FCG3,FcFragmentOfIgG,LowAffinityIIIb,ReceptorFor(CD16),LowAffinityImmunoglobulinGammaFcRegionReceptorIII-B,Fc-GammaReceptorIIIb(CD16),Fc-GammaRIII,CD16bAntigen,IGFR3,CD16.
Introduction
FCGR3B,alsoknownasCD16bbelongstotheIgsuperfamily.FCGR3Bencodesaglycosylphosphatidylinositol(GPI)-anchoredproteinwhichisexpressedconstitutivelybyneutrophils.FCGR3BbindstocomplexoraggregatedIgGandmonomericIgG.DifferentfromIII-A,FCGR3Bcannotarbitrateantibody-dependentcytotoxicityandphagocytosis.FCGR3Boperatetocaptureimmunecomplexesinperipheralbloodcirculationthatdoesnotactivateneutrophils.
Description
FCGR3BproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining188aminoacids(21-200a.a.)andhavingamolecularmassof21.4kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).FCGR3Bisexpressedwithan8aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
FCGR3Bproteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
EDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNENLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISVEHHHHHH.
SafetyDataSheet
SDS