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Prospec/CD8B Human, Sf9/CD8B Human Recombinant, Sf9/1µg/PRO-2508-1µg
Cataloguenumber
PRO-2508
Synonyms
CD8bMolecule,CD8Antigen,BetaPolypeptide1(P37),CD8B1,TLymphocyteSurfaceGlycoproteinBetaChain,T-CellSurfaceGlycoproteinCD8BetaChain,CD8bAntigen,Leu2,LYT3,P37,LY3,T-cellsurfaceglycoproteinCD8betachain.
Introduction
CD8BencodestheCD8betachainisoformsoftheCD8antigen.CD8isacellsurfaceglycoproteinwhichfacilitatesefficientcell-cellinteractionswithintheimmunesystemandislocatedonmostcytotoxicTlymphocytes.TheT-cellreceptorontheTlymphocyteandtheco-receptorCD8antigenidentifyantigensexposedbyanantigenpresentingcell(APC)inthecontextofclassIMHCmolecules.Thefunctionalco-receptoriseitheraheterodimercomposedofonealphaandonebetachainorahomodimercomposedoftwoalphachains.Bothalphaandbetachainssharesubstantialhomologytoimmunoglobulinvariablelightchains.
Description
CD8BproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining158aminoacids(22-170a.a.)andhavingamolecularmassof17.8kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).CD8Bisexpressedwitha6aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD8Bproteinsolution(0.5mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan85.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPHHHHHH.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.