Cataloguenumber
PRO-2499
Synonyms
LowaffinityimmunoglobulinepsilonFcreceptorisoforma,BLAST-2,CD23,CD23A,CLEC4J,FCE2,IGEBF,C-typelectindomainfamily4memberJ,ImmunoglobulinE-bindingfactor,LymphocyteIgEreceptor.
Introduction
FCER2,orFcepsilonRII,isareceptorforIgEwithlowaffinity,whichiscriticaltoregulationofIgElevels.IgEisanantibodyisotypethatattachedtoallergyandresistancetoparasites.FCER2isaC-typelectin,contrarytomanyofthereceptorsforantibodies.FCER2islocatedonactivatedmacrophages,matureBcells,folliculardendriticcells,plateletsandeosinophils.
Description
FCER2producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining283aminoacids(48-321a.a.)andhavingamolecularmassof32.0kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).FCER2isexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
FCER2proteinsolution(0.25mg/ml)containsphosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHSHHHHHH.
SafetyDataSheet
SDS