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Prospec/IP 10 Rhesus macaque/IP-10 Rhesus macaque Recombinant (CXCL10)/25µg/CHM-010-25µg
Cataloguenumber
CHM-010
Synonyms
C-X-Cmotifchemokine10,10kDa,Gamma-IP10,IP-10,Small-inducIBLecytokineB10,CXCL10,SCYB10.
Introduction
Chemokine(C-X-Cmotif)ligand10(CXCL10)isasmallcytokinebelongingtotheCXCchemokinefamilythatisalsoknownas10kDaIP-10.CXCL10issecretedbyseveralcelltypesinresponsetoIFN-?.Thesecelltypesincludemonocytes,endothelialcellsandfibroblasts.CXCL10hasbeenattributedtoseveralroles,suchaschemoattractionformonocytesandTcells,promotionofTcelladhesiontoendothelialcells,antitumoractivity,andinhibitionofbonemarrowcolonyformationandangiogenesis.ThegeneforCXCL10islocatedonhumanchromosome4inaclusteramongseveralotherCXCchemokines.ThischemokineelicitsitseffectsbybindingtothecellsurfacechemokinereceptorCXCR3.Thethree-dimensionalcrystalstructureofthischemokinehasbeendeterminedunder3differentconditionstoaresolutionofupto1.92A.
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