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Prospec/PDGFRB Human/Platelet-Derived Growth Factor Receptor, Beta Human Recombinant/2µg/CYT-1051-2µg
Cataloguenumber
CYT-1051
Synonyms
Platelet-derivedgrowthfactorreceptorbeta,PDGF-R-beta,PDGFR-beta,Betaplatelet-derivedgrowthfactorreceptor,Beta-typeplatelet-derivedgrowthfactorreceptor,CD140antigen-likefamilymemberB,Platelet-derivedgrowthfactorreceptor1,PDGFR-1,CD140b,PDGFRB,BetaPlatelet-DerivedGrowthFactorReceptor,ActivatedTyrosineKinasePDGFRB,CD140bAntigenNDEL1-PDGFRB,EC2.7.10,CD140B,IBGC4,JTK12,PENTT,IMF1,KOGS,PlateletDerivedGrowthFactorReceptorBeta,Platelet-DerivedGrowthFactorReceptor,BetaPolypeptide,Beta-TypePlatelet-DerivedGrowthFactorReceptor,Platelet-DerivedGrowthFactorReceptor1,CD140,Antigen-LikeFamilyMemberB,PDGF-R-Beta,EC2.7.10.1,PDGFR-Beta,PDGFR-1,PDGFR1,PDGFR,Platelet-DerivedGrowthFactorReceptorBeta.
Introduction
Platelet-derivedgrowthfactorreceptorbeta(PDGFRB),belongstotheclassIIIsubfamilyofreceptortyrosinekinases(RTK)whichalsoconsistofthereceptorsforFlt3-ligand,SCFandM-CSF.PDGFRBtakesavitalpartinbloodvesseldevelopmentbypromotinggrowth,migrationaswellasrecruitmentofpericytesandsmoothmusclecellstoendothelialcells.PDGFRBhelpsinrearrangementoftheactinCytoskeletoninadditiontheformationofmembraneruffles.PDGFRBphosphorylates,NCK1,PIK3R1,PTPN11,CBL,SHC1,RASA1/GAPandPLCG1.
Description
PDGFRBproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining739aminoacids(33-532a.a.)andhavingamolecularmassof83.3kDa(MolecularsizeonSDS-PAGEwillappearatapproximately100-150kDa).PDGFRBisexpressedwithan239aminoacidhIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Insectcells.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
PDGFRBproteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
LVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS
