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Prospec/EGFL6 Mouse/EGF Like Domain Multiple 6 Mouse Recombinant/2µg/CYT-1105-2µg
Cataloguenumber
CYT-1105
Synonyms
Epidermalgrowthfactor-likeprotein6,EGF-L6,Egfl6,Maeg.
Introduction
EpidermalGrowthFactorlikeDomainMultiple6(EGFL6)belongstotheEGFrepeatsuperfamilyofproteins,whosemembersareinvolvedintheregulationofcellcycle,proliferation,anddevelopmentalprocesses.EGFL6geneproductcontainsasignalpeptide,suggestingthatEGFL6issecreted;anEGFrepeatregionconsistingoffourcompleteEGF-likerepeatsand1partialEGF-likerepeat,3ofwhichhaveacalcium-bindingconsensussequence;anarg-gly-aspintegrinassociationmotif;andaMAMdomain,whichisassumedtohaveanadhesivefunction.Withinsharedregions,humanEGFL6shares75%and78%aminoacidsequenceidentitywiththemouseandratorthologs,respectively.EGFL6isexpressedinvariousfetaltissuesduringearlydevelopmentsuchasthelung,heart,liver,spleen,cochleaandtheplacenta,aswellasmeningiomatumors.
Description
EGFL6MouseRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining273aminoacids(287-550a.a.)andhavingamolecularmassof31.1kDa(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).EGFL6isexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Insectcells.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
EGFL6proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)containing10%glycerol.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLTMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEGHHHHHH.
SafetyDataSheet
SDS
