Cataloguenumber
CYT-1140
Synonyms
ACVR1A,ALK2,ACVR1,ACTRI,ACTR-I,ACVRLK2,FOP,SKR1,TSRI,ActivinreceptortypeI,Activinreceptor-likekinase2,ALK-2,TSR-I,Serine/threonine-proteinkinasereceptorR1,TGF-BsuperfamilyreceptortypeI.
Introduction
ActivinAReceptorType1(ACVR1)isamemberofTGF-betaserine/threoninekinasereceptorfamily.ACVR1formsareceptorcomplexcontains2typeIIand2typeItransmembraneserine/threoninekinases.TypeIIreceptorsphosphorylateandactivatetypeIreceptorswhichautophosphorylate,bindandactivateSMADtranscriptionalregulators.ACVR1takespartinleft-rightpatternformationduringembryogenesisandisalsoessentialintheBMPpathwaywhichisresponsIBLeforthedevelopmentandrepairoftheskeletalsystem.ACVR1islinkedtoFibrodysplasiaOssificansProgressivawhichisknownfortheformationofheterotopicbonethroughoutthebody.
Description
ACVR1producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining342aminoacids(21-123a.a.)andhavingamolecularmassof38.4kDa.ACVR1isexpressedwitha239aminoacidhIgG-His-TagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
ACVR1proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLELEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS