
Cataloguenumber
CYT-1084
Synonyms
WNT1InducIBLeSignalingPathwayProtein1,CCNFamilyMember4,CCN4,Wnt-1Inducible,SignalingPathwayProtein1,WNT1InducedSecretedProtein1,Wnt-1-InducedSecretedProtein,CTC-458A3.8,WISP1tc,WISP1c,WISP1i,WISP-1,WISP1.
Introduction
WISP1isapartofafamilyofcysteine-rich,glycosylatedsignalingproteinsthatmediatevarieddevelopmentalprocesses.WISP1isaDownstreamregulatorintheWnt/Frizzled-signalingpathwayandislinkedwithcellsurvival.WISP1weakensp53-mediatedapoptosisinresponsetoDNAdamagethroughactivationofAKTkinaseandup-regulatestheanti-apoptoticBcl-X(L)protein.
Description
WISP1HumanRecombinantproducedinMousemyelomacelllineisasingle,glycosylatedpolypeptidechaincontaining355aminoacids(Thr23-Asn367),havingamolecularmassof39.3kDaandfusedtoa10aaHisTag.
TheWISP1ispurifiedbyproprietarychromatographictechniques.
Source
HEK293Cells.
PhysicalAppearance
Formulation
WISP1proteinwaslyophilizedfroma0.2µmfilteredsolutioninPBS.
Solubility
Itisrecommendedtoadddeionizedwatertoprepareaworkingstocksolutionofapproximately0.5mg/mlandletthelyophilizedpelletdissolvecompletely.
StABIlity
Storelyophilizedproteinat-20°C.Aliquottheproductafterreconstitutiontoavoidrepeatedfreezing/thawingcycles.Reconstitutedproteincanbestoredat4°Cforalimitedperiodoftime;itdoesnotshowanychangeaftertwoweeksat4°C.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
TALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRG
LYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRR
VSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCW
PEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQC
PDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIANHHHHHHHHHH.
SafetyDataSheet
SDS