
Cataloguenumber
CYT-1039
Synonyms
TNFRSF4,TNFReceptorSuperfamilyMember4,TAXTranscriptionally-ActivatedGlycoprotein1Receptor,OX40LReceptor,ACT35Antigen,CD134Antigen,TXGP1L,Tax-TranscriptionallyActivatedGlycoprotein1Receptor,TumorNecrosisFactorReceptorSuperfamily,Member4,TumorNecrosisFactorReceptorSuperfamilyMember4,LymphoidActivationAntigeneACT35,OX40CellSurfaceAntigen,OX40Homologue,ATC35Antigen,OX40Antigen,ACT35,CD134,IMD16,OX40.
Introduction
TNFRSF4,alsoknownasTNFReceptorSuperfamilyMember4,isaTcellco-stimulatorymoleculewhichbelongstotheTNFreceptorsuperfamily.TNFRSF4coordinateswithotherco-stimulatorysubstancessuchasCD28,CD40,CD30,CD27and4-1BBtocontroltheactivationoftheimmuneresponse.TNFRSF4takesavitalpartinantigen-specificTcellexpansionaswellassurvival.TNFRSF4isup-regulatedonCD4+andCD8+TcellsuponengagementoftheTCRbyantigenpresentingcellsalongwithco-stimulationbyCD40-CD40LigandandCD28-B7.Inaddition,TNFRSF4regulatescytokineproductionfromTcells,antigenpresentingcells,naturalkillercellsandnaturalkillercells.TNFRSF4regulatescytokinereceptorsignaling.
Description
TNFRSF4producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining425aminoacids(29-214a.a.)andhavingamolecularmassof46.9Da.(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).TNFRSF4isexpressedwitha239aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TNFRSF4proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
LHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRALEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
SafetyDataSheet
SDS