
Cataloguenumber
CYT-1082
Synonyms
CDF,HILDA,D-FACTOR,Differentiation-stimulatingfactor,Melanoma-derivedLPLinhibitor,MLPLI,Emfilermin,Leukemiainhibitoryfactor,LIF,DIA.
Introduction
LeukemiaInhibitoryFactoralsocalledLIFisalymphoidfactorthatpromoteslong-termmaintenanceofembryonicstemcellsbysuppressingspontaneousdifferentiation.LeukemiaInhibitoryFactorhasseveralfunctionssuchascholinergicneurondifferentiation,controlofstemcellpluripotency,bone&fatmetabolism,mitogenesisoffactordependentcelllines&promotionofmegakaryocyteproductioninvivo.HumanandmouseLIFexhibita78%identityinitsaminoacidsequence.
Description
LIFHumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechain(a.a23-202)containing189aminoacidsincludinga9a.aN-terminalHistag.Thetotalmolecularmassis20.9kDa(calculated).
Source
EscherichiaColi.
PhysicalAppearance
Formulation
LIFfiltered(0.4µm)andlyophilizedfrom0.5mg/mlsolutionin20mMTrisbuffer,20mMNaCland5%w/vtrehalose,pH7.5.
Solubility
Itisrecommendedtoadddeionizedwatertoprepareaworkingstocksolutionofapproximately0.5mg/mlandletthelyophilizedpelletdissolvecompletely.
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MKHHHHHHASPLPITPVNATCAIRHPCHNNLMNQIRSQLAQLNGSANALFILYYTAQGEPFPNNLDKLCGPNVTDFPPFHANGTEKAKLVELYRIVVYLGTSLGNITRDQKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVGHVDVTYGPDTSGKDVFQKKKLGCQLLGKYKQIIAVLAQAF.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.