
Cataloguenumber
cyt-1067
Synonyms
Interleukin5ReceptorSubunitAlpha,Interleukin5Receptor,Alpha,IL-5ReceptorSubunitAlpha,IL-5RSubunitAlpha,CD125Antigen,CDw125,IL5R,Interleukin-5ReceptorSubunitAlpha,Interleukin-5ReceptorAlphaChain,Interleukin5ReceptorType3,IL-5R-Alpha,HSIL5R3,IL-5RA,CD125,Interleukin-5receptorsubunitalpha,IL-5receptorsubunitalpha,IL-5Rsubunitalpha,IL-5R-alpha,IL-5RA.
Introduction
Interleukin-5receptorsubunitalpha(Il5ra)regulatesthedevelopmentandfunctionofeosinophils.TheIl5raproteinisatherapeutictargetforhypereosinophilicdiseasesincludingallergicinflammationsandasthma.Oct2enhancesantibody-secretingcelldifferentiationviaregulationofIl5rachainexpressiononactivatedBcells.
Description
IL5RAproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining331aminoacids(21-342a.a.)andhavingamolecularmassof37.8kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).IL5RAisexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL5RAproteinsolution(0.5mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPDLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWHHHHHH.
SafetyDataSheet
SDS