
Cataloguenumber
CYT-1137
Synonyms
IL-31,Interleukin31,IL31.
Introduction
IL-31producedbyactivatedTh2-typeTcells,cooperateswithaheterodimericreceptorconsistingofIL-31ReceptorAnatagoNISTandOnconstatin-MReceptorthatiscontinueslyexpressedonepithelialcellsandkeratinocytes.IL-31playsaroleinthepromotionofallergicskindisordersandinregulatingotherallergicdiseases,suchasasthma.IL-31isinvolvedintheitchingsensationandendorsesthescratchingbehaviorinNC/Ngamicewithatopicdermatitis.IL-31expressionisconnectdwithCLA(+)Tcellsandcontributestothedevelopmentofatopicdermatitis-inducedskininflammationandpruritus.IL-31isapowerfulinducerofproinflammatorymediatorsinhumancolonicSEMFs.IL-31takespartasaproinflammatorycytokinederivedfromTh2cells.SerumIL-31levelishigherinpatientswithatopicdermatitis.IL-31isinvolvedinabroadrangeofimmune-&non-immunecells&possessespotentialpleiotropicphysiologicalfunctions,includingregulatinghematopoiesis&immuneresponse,causinginflammatoryboweldisease,airwayhypersensitivity&dermatitis.
Description
IL31CanineproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining136aminoacids(24-159aa)andhavingamolecularmassof15.3kDa.IL31ispurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
TheIL31solution(0.25mg/ml)contains20%GlycerolandPhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
SHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQ
SafetyDataSheet
SDS