
Cataloguenumber
CYT-1020
Synonyms
Interleukin2ReceptorSubunitAlpha,Interleukin2Receptor,Alpha,IL-2ReceptorSubunitAlpha,IL-2RSubunitAlpha,TACAntigen,P55,Insulin-DependentDiabetesMellitus10,Interleukin-2ReceptorSubunitAlpha,CD25Antigen,IL-2-RA,IDDM10,IL2-RA,IMD41,TCGFR,CD25,IL2R.
Introduction
IL2-RaisoneofthethreeconstituentsubunitsoftheIL2receptor.IL-2RaisreleasedintotheserumafterincreasedcellularexpressionsuchasincreasedactivationofBandTcells.ClinicalmanifestationsofIL2-Raelevationincludeautoimmuneconditionsandsomeleukemiasandlymphomas.
Description
IL2RAproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining461aminoacids(22-240a.a.)andhavingamolecularmassof52.1kDa(MolecularsizeonSDS-PAGEwillappearatapproximately50-70kDa).IL2RAisexpressedwitha239aminoacidhIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL2RAproteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS