
Cataloguenumber
CYT-1136
Synonyms
IRAP,IL1F3,IL1RA,IL-1ra3,ICIL-1RA,IL1RN,IL1inhibitor,IL-1ra,F630041P17Rik.
Introduction
Interleukin-1raisamemberoftheinterleukin1cytokinefamily.IL1RAinhibitstheactivitiesofinterleukin1,alpha(IL1A)andinterleukin1,beta(IL1B),andmodulatesavarietyofinterleukin1relatedimmuneandinflammatoryresponses.IL1RAandfiveothercloselyrelatedcytokinegenesformageneclusterspanningapproximately400kbonchromosome2.Apolymorphismofthisgeneisreportedtobeassociatedwithincreasedriskofosteoporoticfracturesandgastriccancer.
Description
IL1RAMouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining177aminoacids(27-178aa)andhavingamolecularmassof20kDa.IL1RAisfusedtoa25aminoacidHistagatN-terminusandpurifiedbyproprietarychromatographictechniques.
Source
EscherichiaColi.
PhysicalAppearance
Formulation
TheIL1RAsolution(1mg/ml)contains10%Glycerol,20mMTris-HClbuffer(pH8.0)and0.1MNaCl
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
BIOLOGicalActivity
MeasuredbytheabilitytoinhibitproliferationusingD10.G4.1mousehelperTcells.ED50forthiseffectis≤60ng/mlwithMouseIL-1alpha.
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSHMRPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNIKLEEKIDMVPIDLHSVFLGIHGGKLCLSCAKSGDDIKLQLEEVNITDLSKNKEEDKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADRPVSLTNTPEEPLIVTKFYFQEDQ
SafetyDataSheet
SDS