
Cataloguenumber
CYT-1078
Synonyms
Interleukin18Receptor1,CD218Antigen-LikeFamilyMemberA,IL1Receptor-RelatedProtein,IL-18R-1,CDw218a,IL-18R1,IL-1Rrp,IL1R-Rp,IL1RRP,Interleukin-18Receptor1,CytokineReceptor,CD218aAntigen,IL18Ralpha2,CD218a,IL18RA.
Introduction
IL18R1(interleukin18receptor1)isaninterleukinreceptorwhichispartoftheimmunoglobulinsuperfamily.IL18R1comprises3Ig-likeC2-typedomains,onTIRdomainIL18R1sharesmanyimmuno-regulatoryfunctionswithIL12.IL12andIFN-alphaarefoundtoinducetheexpressionofIL18receptorinNK&Tcells.Moreover,IL18R1explicitlybindsinterleukin18,andisvitalforIL18mediatedsignaltransduction.IL18R1doesnotbindIL1AorIL1Bbeta,howeveritdoesbindtotheagoNISTwhichcausesNF-kappa-Btobecomeactive.
Description
IL18R1producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontainingatotalof550aminoacids(19-329a.a.)andhavingamolecularmassof62.7kDa(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).IL18R1isexpressedwitha239aminoacidhIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL18R1proteinsolution(0.5mg/ml)contains10%glycerol&Phosphatebufferedsaline(pH7.4).
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
AESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
SafetyDataSheet
SDS