Cataloguenumber
CYT-1023
Synonyms
Interleukin17ReceptorA,IL-17ReceptorA,IL-17RA,CDw217,IL17R,Interleukin-17ReceptorA,Interleukin17Receptor,CD217Antigen,HIL-17R,CANDF5,CD217,IMD51.
Introduction
Interleukin-17receptorAisoform1(IL17RA)isacytokinereceptorwhichbindsinterleukin17.IL17RAisapotentinducerofthematurationofCD34-positivehematopoieticprecursorsintoneutrophils.IL17RAisatype1membraneglycoproteinwhichbindswithlowaffinitytointerleukin17A.TheIL17RAproteinandInterleukin17Ahasapathogenicroleinmanyinflammatoryandautoimmunediseasessuchasrheumatoidarthritis.
Description
IL17RAHumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining527aminoacids(33-320)andhavingamolecularmassof60.4kDa(MolecularsizeonSDS-PAGEwillappearatapproximately70-100kDa).IL17RAisfusedtoa239aminoacidshIgG-His-TagatC-terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
IL17RAproteinsolution(0.5mg/ml)containingPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan90%asdeterminedbySDS-PAGE.
Aminoacidsequence
LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS
