Cataloguenumber
CYT-1004
Synonyms
Interleukin-17B,IL-17B,CytokineZcyto7,Interleukin-20,Neuronalinterleukin-17-relatedfactor,IL20,NIRF,ZCYTO7.
Introduction
IL-17familymembersareglycoproteinssecretedasdimerswhichinducelocalcytokineproductionandrecruitgranulocytestositesofinflammation.TheIL-17familyiscomprisedofatleastsixpro-inflammatorycytokinesthatshareaconservedcysteine-knotstructurebutdivergeattheN-terminus.IL-17isinducedbyIL-15andIL-23,mostlyinactivatedCD4+TcellsdistinctfromTh1orTh2cells.IL-17BbindstheIL-17Breceptor,butnottheIL-17receptor;itismosthomologouswithIL-17D,whichisexpressedbyrestingCD4+TcellsandCD19+Bcells.IL17BDiseasesassociatedwithIL17Bincludespondyloarthropathy,andneuronitis,andamongitsrelatedsuper-pathwaysareMucinexpressioninCFviaIL-6,IL-17signalingpathwaysandSTAT3Pathway.
Description
IL17BHumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining169aminoacids(21-180a.a.)andhavingamolecularmassof19.2kDa(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).IL17Bisexpressedwitha6aminoacidHis-tagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL17Bproteinsolution(0.25mg/ml)containsPhosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIFHHHHHH.
SafetyDataSheet
SDS

