Cataloguenumber
CYT-602
Synonyms
Interleukin-28A,IL-28A,IFN-LamBDa2,IFN-Lambda2,CytokineZCYTO20,IL28A,IFNL2,ZCYTO20.
Introduction
IL-28AisdistantlyrelatedtotypeIIFNsandtheIL-10family.ExpressionofIL-28AisinducedbyviralinfectionwhichinteractswithaheterodimericclassIIcytokinereceptorthatconsistsofinterleukin10receptor,beta(IL10RB)andinterleukin28receptor,alpha.IL-28AexhibitscommonfeatureswithtypeIIFNssuchasantiviralactivity,antiproliferativeactivityandinvivoantitumouractivity.IL-28AactssimilarlytoIFNs,butislesseffectivegenerallyandhasactivityinamorelimitedrangeofcelllines.IFN-ambda1,IFN-lambda2andIFN-lambda3arecloselypositionedgenesonhumanchromosome19.IL-28AinducesELR(-)CXCchemokinemRNAinhumanperipheralbloodmononuclearcells,inanIFN-gamma-independentmanner.IL-28AisabletogeneratetolerogenicDCs,anactivitythatcouldthwartIFN-betafunctions.IL-28Aproducedinresponsetoviralinfection,activatesbothmonocytesandmacrophagesproducingarestrictedpanelofcytokinesandthereforeisanimportantfactorinactivatinginnateimmuneresponsesatthesiteofviralinfection.
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