
Cataloguenumber
CYT-1005
Synonyms
BMPR1A,10q23del,ACVRLK3,ALK3,CD292,SKR5,BoneMorphogeneticProteinReceptorType1A,BoneMorphogeneticProteinReceptor,TypeIA,Serine/Threonine-ProteinKinaseReceptorR5,ActivinReceptor-LikeKinase3,BMPType-1AReceptor,EC2.7.11.30,ALK-3,BoneMorphogeneticProteinReceptorType-1A,ActivinAReceptor,TypeII-LikeKinase3,CD292Antigen,EC2.7.1.
Introduction
Thebonemorphogeneticprotein(BMP)receptorsareafamilyoftransmembraneserine/threoninekinasesthatincludethetypeIreceptorsBMPR1AandBMPR1BandthetypeIIreceptorBMPR2.Thesereceptorsarealsocloselyrelatedtotheactivinreceptors,ACVR1andACVR2.TheligandsofthesereceptorsaremembersoftheTGF-betasuperfamily.TGF-betasandactivinstransducetheirsignalsthroughtheformationofheteromericcomplexeswith2differenttypesofserine(threonine)kinasereceptors:typeIreceptorsofabout50-55kDandtypeIIreceptorsofabout70-80kD.TypeIIreceptorsbindligandsintheabsenceoftypeIreceptors,buttheyrequiretheirrespectivetypeIreceptorsforsignaling,whereastypeIreceptorsrequiretheirrespectivetypeIIreceptorsforligandbinding.
Description
BMPR1AHumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining371aminoacids(24-152a.a.)andhavingamolecularmassof41.4kDa(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).BMPR1Aisfusedwitha242aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
BMPR1Aproteinsolution(1mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Aminoacidsequence
ADPQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS