
Cataloguenumber
CYT-1002
Synonyms
ADIponectin,C1QAndCollagenDomainContaining,AdiposeMostAbundantGeneTranscript1Protein,AdipocyteComplement-Related30KDaProtein,30KDaAdipocyteComplement-RelatedProtein,ACRP30,APM-1,GBP28,ACDC,APM1,Adipocyte,C1qAndCollagenDomain-ContainingProtein,Adipocyte,C1QAndCollagenDomainContaining,AdiposeMostAbundantGeneTranscript1,AdiposeSpecificCollagen-LikeFactor,Gelatin-BindingProtein28,Gelatin-BindingProtein,AdiponectinPrecursor,Adiponectin,ADIPQTL1,ADPN,30kDaadipocytecomplement-relatedprotein,dipocytecomplement-related30kDaprotein,ACRP30,Adipocyte,C1qandcollagendomain-containingprotein,Adiposemostabundantgenetranscript1protein,apM-1,Gelatin-bindingprotein.
Introduction
TheadiposetissueexclusivelyexpressesandsecretesAdiponectin(Acrp30).Acrp30isinvolvedinvariousphysiologicalprocessessuchasenergyhomeostasis,insulinsensitivity,hormonalprocesses,fattyacidmetabolismandobesity.Adiponectincirculatesintheplasma.DecreasedlevelsofAdiponectinareassociatedwithinsulinresistanceandhyperinsulinemia,asseeninpeoplewithobesityinsulinresistance,anddiabetestype2,whoseplasmalevelsofadiponectinarereduced.ThemodularstructureofAcrp30iscomprisedofN-terminalcollagenousdomainfollowedbyaC-terminalglobulardomain.Acrp30alsoactsasasignificantnegativeregulatorinhematopoiesisandimmunesystems;itmaybeinvolvedinendinginflammatoryresponsesthroughitsinhibitoryfunctions.AdiponectininhibitsendothelialNF-kappa-bsignalingthroughacAMP-dependentpathway,italsoinhibitsTNF-alpha-inducedexpressionofendothelialadhesionmolecules.
Description
Acrp30HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining146aminoacids(106-242a.a.)andhavingamolecularmassof16.9kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately13.5-18kDa).Acrp30isexpressedwitha6aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
ADPEGAYVYRSAFSVGLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLYHDHHHHHH.
SafetyDataSheet
SDS