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Prospec/PPP3CA antibody/Mouse Anti Human Protein Phosphatase 3, Catalytic subunit, Alpha Isozyme/100µg/ANT-737-100µg-100µg
Cataloguenumber
ANT-737
Synonyms
Serine/threonine-proteinphosphatase2Bcatalyticsubunitalphaisoform,CAM-PRPcatalyticsubunit,Calmodulin-dependentcalcineurinAsubunitalphaisoform,PPP3CA,CALNA,CAN,CALN,CCN1,CNA1,PPP2B,CALNA1.
Type
Introduction
PPP3CA(akaCalcineurinA)isamajorsolublecalmodulinbindingproteininthebrainandaCa2+/calmodulindependentserine/threonineproteinphosphatase,witharelativelylimitedsubstratespecificity.PPP3CAactivatestheTcellsoftheimmunesystemandcanbeblockedbydrugs.PPP3CAactivatesNFATc(atranscriptionfactor)bydephosphorylatingit.TheactivatedNFATcissubsequentlytranslocatedintothenucleus,whereitupregulatestheexpressionofinterleukin2.
Clone
PAT1E11AT.
PhysicalAppearance
Immunogen
Anti-humanPPP3CAmAb,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanPPP3CAprotein1-511aminoacidspurifiedfromE.coli.
IgSubclass
MouseIgG2bheavychainandklightchain.
PurificationMethod
PPP3CAantibodywaspurifiedfrommouseasciticfluidsbyprotein-Aaffinitychromatography.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.02%SodiumAzide.
StorageProcedures
StABIlity/ShelfLife
Applications
PPP3CAantibodyhasbeentestedbyELISAandWesternblotanalysistoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.
SafetyDataSheet
SDS