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Prospec/PPARGC1A Antibody/Mouse Anti Human PPARG Coactivator 1 Alpha/20µg/ANT-697-20µg-20µg

Cataloguenumber
ANT-697
Synonyms
Peroxisomeproliferator-activatedreceptorgammacoactivator1-alpha,PGC-1-alpha,PPAR-gammacoactivator1-alpha,PPARGC-1-alpha,Ligandeffectmodulator6,LEM6,PGC1,PGC1A,PPARGC1,PPARGC1A.
Type
Introduction
PPARGC1AistranscriptionalcoactivatorforsteroidreceptorsandnuclearreceptorswhichincreasesthetranscriptionalactivityofPPARGandthyroidhormonereceptorontheuncouplingproteinpromoter.PPARGC1AregulatesmainmitochondrialgenesthatcontributetotheprogramofadaptiveThermogenesisandplaysanimportantroleinmetabolicreprogramminginresponsetodietaryavailABIlitythroughcoordinationoftheexpressionofmanygenesparticipateinglucoseandfattyacidmetabolism.PPARGC1AinducestheexpressionofPERM1intheskeletalmuscleandtakespartintheintegrationofthecircADIanrhythmsandenergymetabolism.
Clone
PAT25C8AT.
PhysicalAppearance
Immunogen
Anti-humanPPARGC1AmAb,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanPPARGC1Aprotein300-540aminoacidspurifiedfromE.coli.
IgSubclass
MouseIgG2aheavychainandklightchain.
PurificationMethod
PPARGC1Aantibodywaspurifiedfrommouseasciticfluidsbyprotein-Aaffinitychromatography.
Formulation
1mg/mlcontainingPBS,pH-7.4,10%Glyceroland0.02%SodiumAzide.
StorageProcedures
Stability/ShelfLife
Applications
PPARGC1AantibodyhasbeentestedbyELISA,Westernblotanalysis,FlowcytometryandICC/IFtoassurespecificityandreactivity.Sinceapplicationvaries,however,eachinvestigationshouldbetitratedbythereagenttoobtainoptimalresults.
SafetyDataSheet
SDS