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Prospec/ESR1 Antibody/Estrogen Receptor Alpha, Mouse Anti Human/1mg/ANT-473-1mg-1mg

Cataloguenumber
ANT-473
Synonyms
Type
Introduction
Estrogenreceptorsα(ERα,ER;NR3A1)isamemberofthesteroidhormonereceptorfamily.ERαisaligand-activatedtranscriptionfactor.ERαcontainDNAbindingandligandbindingdomains.ERαisexpressedinawidevarietyoftissues,includingovary,uterus,breast,prostate,testis,epididymis,bones,bladder,kidney,heart,vesselwall,pituitaryglandandhypothalamus.ERplaysavarietyofimportantrolesinthemaintenanceofthereproductive,cardiovascular,musculoskeletalandcentralnervoussystems.ThenaturalligandforERis17β-estrADIol,theclassicalestrogeniccompound.ThebindingofestrogentoERinducesaconformationalchangeandtriggersacascadeofevents,includingdissociationfromheatshockproteins,receptordimerization,phosphorylationandtheassociationofthehormoneactivatedreceptorwithspecificregulatoryelementsintargetgenes.
Clone
LSERASC1.
Immunogen
IgSubclass
PurificationMethod
Formulation
1mg/mlinPBS(afterreconstitution).
StorageProcedures
Solubility
Applications
AvailableConjugates
SafetyDataSheet
SDS