>
产品中心 >
Anti_Human >
Prospec/CD11b Antibody, FITC/CD11b, Mouse Anti-Human, FITC/1mg/ANT-276-1mg-1mg
Catalogue number
ANT-276
Synonyms
Type
Introduction
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ("Mac-1"), or inactivated-C3b (iC3b) receptor 3 ("CR3"). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain.
Clone
Immunogen
Ig Subclass
Purification Method
Formulation
Storage Procedures
Solubility
Applications
Available Conjugates
Safety Data Sheet
SDS