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Prospec/ISG15 Human/ISG15 Human Recombinant/10µg/PRO-611-10µg-10µg
Cataloguenumber
PRO-611
Synonyms
ISG15,G1P2,IFI15,UCRP,ISG15Ubiquitin-likemodifier.
Introduction
ISG15ubiquitin-likeModifierisconjugatedtotheintracellulartargetproteinsafterIFN-alphaorIFN-betastimulation.ISG15enzymaticpathwayispartiallydistinctfromthatofubiquitin,differinginsubstratespecificityandinteractionwithligatingenzymes.ISG15conjugationpathwayusesadedicatedE1enzyme,butseemstoconvergewiththeubconjugationpathwayatthelevelofaspecificE2enzyme.ISG15proteintargetsincludeSTAT1,SERPINA3G/SPI2A,JAK1,MAPK3/ERK1,PLCG1,EIF2AK2/PKR,MX1/MXA,andRIG-1.DeconjugatedbyUSP18/UBP43showsspecificchemotacticactivitytowardsneutrophilsandactivatesthemtoinducereleaseofeosinophilchemotacticfactors.ISG15servesasatrans-actingbindingfactordirectingtheassociationofligatedtargetproteinstointermediatefilaments.ISG15playsaroleinautocrine,paracrineandendocrinemechanisms,asincell-to-cellsignaling,possIBLypartlybyinducingifn-gammasecretionbymonocytesandmacrophages.ISG15displaysantiviralactivityduringviralinfections.ISG15inresponsetoIFN-TAUsecretedbytheconceptus,ligatestoandregulateproteinsinvolvedinthereleaseofprostaglandinF2-alphaandthuspreventlysisofthecorpusluteumandmaintainthepregnancy.ISG15sharesseveralcommonpropertieswithotherubiquitin-likemolecules,butitsactivityisstronglyregulatedbyprecisesignalingpathwaysthathavearoleininnateimmunity.
Description
Source
PhysicalAppearance
Formulation
StABIlity
Purity
Greaterthan98.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
SafetyDataSheet
SDS