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Prospec/SNCG Mouse/Gamma-Synuclein Mouse Recombinant/50µg/PRO-2490-50µg-50µg

Cataloguenumber
PRO-2490
Synonyms
Gamma-synuclein,Persyn.
Introduction
g-synuclein(Originallyknownasabreastcancerspecificgeneproduct,BCSG1)isanacidicneuronalproteinof127aminoacids.Gamma-SynucleinisamemberoftheSynucleinproteinfamily,whichisbelievedtobeinvolvedinthepathogenesisofneurodegenerativediseases.HighlevelsofGamma-SynucleinhavebeenfoundinadvancedbreastcarcinomassuggestingacorrelationbetweenoverexpressionofSNCGandbreasttumordevelopment.Synuclein-Gammaisfoundmostlyintheperipheralnervoussystem(inprimarysensoryneurons,sympatheticneurons,andmotorneurons)andretina.SNCGisalsoidentifiedinthebrain,ovariantumors,andintheolfactoryepithelium.SNCGexpressioninbreasttumorsisaMarkerfortumorprogression.Amodificationintheexpressionofgamma-synucleinhasbeendetectedintheretinaofAlzheimer"spatients.
Description
SNCGMouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining146aminoacids(1-123a.a)andhavingamolecularmassof15.5kDa.SNCGisfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
SNCGproteinsolution(1mg/ml)containing20mMTris-HCl(pH8.0)and0.1MNaCl.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSMDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKENVVQSVTSVAEKTKEQANAVSAVVSSVNTVANKTVEEAENIVVTTGVVRKEDLEPPAQDQEAKEQEENEEAKSGED.
SafetyDataSheet
SDS