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Prospec/RARRES2 Human/Retinoic Acid Receptor Responder 2 Human Recombinant/1mg/PRO-788-1mg-1mg

Cataloguenumber
PRO-788
Synonyms
Chemerin,TIG2,Retinoicacidreceptorresponderprotein2,RAR-responsiveproteinTIG2,RARRES2,HP10433.
Introduction
RARRES2isasecretedchemotacticproteinthatinitiateschemotaxisthroughtheChemR23Gprotein-coupledseven-transmembranedomainligand.RARRES2actsasanADIpokine,andistruncatedonbothterminifromtheproprotein.RARRES2isstructurallyrelatedtothecathelicidinprecursors,cystatinCandkininogens.RARRES2promotescalciummobilizationandchemotaxisofimmaturedendriticcellsandmacrophages.RARRES2issecretedasaprecursoroflittleBIOLOGicalactivity,whichrequiresproteolyticcleavageofitsCOOH-terminaldomaintobeexchangeedintoapotentandhighlyspecificagoNISTofChemR23.RARRES2signalsviaitsreceptor,ChemR23(CMKLR1),asapositiveregulatorofadipocytedifferentiationandmetabolicfunction.TheChemerinreceptoractsasacoreceptorforSIVandsomeprimaryHIV-1strains.
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