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Prospec/RARRES2 Human/Retinoic Acid Receptor Responder 2 Human Recombinant/25µg/PRO-788-25µg-25µg
Catalogue number
PRO-788
Synonyms
Chemerin, TIG2, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433.
Introduction
RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains.
Description
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Safety Data Sheet
SDS