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Prospec/PDCD1 Human/Programmed Cell Death 1 Human Recombinant/10µg/PRO-2442-10µg-10µg

Cataloguenumber
PRO-2442
Synonyms
ProgrammedCellDeath1,SystemicLupusErythematosusSusceptibility2,ProteinPD-1,HPD-1,PD1,ProgrammedCellDeath1Protein,ProgrammedCellDeathProtein1,CD279Antigen,CD279,HPD-L,HSLE1,SLEB2,PD-1.
Introduction
PDCD1isacellsurfacemembraneproteinoftheimmunoglobulinsuperfamily.PDCD1isexpressedinpro-B-cellsandisthoughttohavearoleintheirdifferentiation.Inmice,expressionofPDCD1geneisinducedinthethymuswhenanti-CD3antibodiesareinjectedandlargenumbersofthymocytesundergoapoptosis.MicedeficientforthePDCD1genebredonaBALB/cbackgrounddevelopeddilatedcardiomyopathyanddiedfromcongestiveheartfailure.ThesestudiessuggestthatthePDCD1geneproductmayalsobeimportantinTcellfunctionandcontributetothepreventionofautoimmunediseases.
Description
PDCD1HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining392aminoacids(21-170a.a.)andhavingamolecularmassof44.0kDa(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).PDCD1isexpressedwitha239aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
PDCD1proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS