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Prospec/SHBG Human/Sex Hormone-Binding Globulin Human Recombinant/2µg/PRO-1603-2µg-2µg
Catalogue number
PRO-1603
Synonyms
Introduction
Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.
Description
Source
Physical Appearance
Formulation
SHBG filtered solution at a concentration of 55.6µg/ml in certified FBS (Fetal Bovine Serum 5%).
Stability
Amino acid sequence
Safety Data Sheet
SDS