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Other_recombinant_protein >
Prospec/Histone Bovine/Bovine Histone/50µg/PRO-2558-50µg-50µg
Cataloguenumber
PRO-2558
Introduction
HistoneisvastlyalkalineproteinexistsineukaryoticcellnucleiwhichsetanddirecttheDNAintostructuralunitsnamednucleosomes.5keyfamiliesofhistonesare:H1/H5,H2A,H2B,H3,includingH4.ThecorehistonesareH2A,H2B,H3andH4,whereashistonesH1/H5areidentifiedasthelinkerhistones.Moreoverthedynamicsofchromatinstructuredependonposttranslationalmodificationofhistonesinadditiontotheappearanceofdifferenthistonevariants.HistoneH3aswellasH4aremodifiedcovalentlyatseveralresidues.ThehistonecodeisconstitutebytheseandtheH2A/H2Bmodifications.
Description
HistoneBovineispurifiedfrombovinetissuesbyproprietaryprotein-chemicaltechniques.
Source
Bovinetissues.
PhysicalAppearance
Formulation
HistoneBovineissuppliedin20mMHEPESbufferpH-7.6,250mMNaCland20%glycerol.
StABIlity
Purity
Coatingconcentration
0.2-0.5μg/ml(dependingonthetypeofELISAplateandcoatingbuffer).Suitableforlabelingoffunctionalgroups.
SafetyDataSheet
SDS
Immunologicalfunctions
1.BindsIgGtypehumanautoantibodies.2.Checkerboard/immunodotanalysisofpositive/negativesamples.