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Other_recombinant_protein >
Prospec/HCST Human/Hematopoietic Cell Signal Transducer Human Recombinant/1mg/PRO-2522-1mg-1mg

Cataloguenumber
PRO-2522
Synonyms
HematopoieticCellSignalTransducer,DNAX-ActivationProtein10,Phosphoinositide-3-KinaseAdaptorProtein,TransmembraneAdapterProteinKAP10,KinaseAssocProOf~10kDa,MembraneProteinDAP10,PIK3AP,DAP10,KAP10,KinaseAssocProtein.
Introduction
HCST(HematopoieticCellSignalTransducer)ispartoftheDAP10family.HCSTiscapableofbeingapartofanimmunoreceptorcomplex.HCSTtakesavitalpartininducingcytotoxicityagainstMHCclassIchain-associatedMICA&targetcellsexpressingcellsurfaceligandssuchasUL16-bindingprotein(ULBP)&MICB.HCSTcomplexparticipatesinproliferationaswellascellsurvivalbyactivatingT&NKcellresponses.
Description
HCSTproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining271aminoacids(20-48a.a.)andhavingamolecularmassof30.1kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).HCSTisexpressedwitha242aminoacidhIgG-His-tagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
HCSTproteinsolution(1mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPTTPGERSSLPAFYPGTSGSCSGCGSLSLPLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS