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Prospec/FRZB Human, Sf9/Frizzled-Related Protein Human Recombinant, Sf9/50µg/PRO-2551-50µg-50µg

Cataloguenumber
PRO-2551
Synonyms
Secretedfrizzled-relatedprotein3,sFRP-3,Frezzled,Fritz,Frizzled-relatedprotein1,FrzB-1,FRZB,FIZ,FRE,FRP,FRZB1,SFRP3,OS1,FZRB,hFIZ,FRP-3,SFRP3,SRFP3,FRZB-PEN.
Introduction
Frizzled-RelatedProtein(FRZB)isasecretedproteinwhichisinvolvedintheregulationofbonedevelopment.FRZBgenedefectscausethefemale-specificosteoarthritis(OA)susceptibility.sFRPS(Solublefrizzled-relatedproteins)serveasmodulatorsofWntsignalingbydirectinteractionwithWnts.sFRPShavearoleinregulatingcellgrowthanddifferentiationinspecificcelltypes.SFRP3/FRZBisinvolvedinlimbskeletogenesis.FRZBregulateschondrocytematurationandlongbonedevelopment.
Description
FRZBproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining302aminoacids(33-325a.a.)andhavingamolecularmassof34.2kDa(MolecularsizeonSDS-PAGEwillappearatapproximately28-40kDa).FRZBisexpressedwitha9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
TheFRZBsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARNHHHHHH.
SafetyDataSheet
SDS