>
产品中心 >
Other_recombinant_protein >
Prospec/HSPA5 Mouse/Heat Shock 70kDa protein 5 Recombinant Mouse/5µg/HSP-036-5µg-5µg

Cataloguenumber
HSP-036
Synonyms
78kDaglucose-regulatedprotein,GRP-78,Heatshock70kDaprotein5,Immunoglobulinheavychain-bindingprotein,Bip,Hspa5,Grp78,HSPA5,Hsce70.
Introduction
OnceChinesehamsterK12cellsarestarvedfromglucose,thesynthesisofGRP(glucose-regulatedprotein)expressed.HSPA5alsocalledBiP,ispartoftheHSP70familyandplaysaroleinthefoldingandassemblyofproteinsintheendoplasmicreticulum.HSPA5playsakeyroleinmonitoringproteintransportthroughthecell.HSPA5isastressresponseproteinwhichisinducedbyagentsorconditionsthatadverselyaffectendoplasmicreticulumfunction.HSPA5iscrucialfortheproperglycosylation,foldingaswellasforthemaintenanceofcellhomeostasisandthepreventionofapoptosis.HSPA5isdifferentiallyexpressedinthedorsolateralprefrontalcortexfrompatientswithschizophrenia.HSPA5guidesposttranslationalhepatitisBviruslargeenvelopeproteinimportintothemammalianER.HSPA5activelyregulatesmultiplemalignantphenotypes,includingcellgrowth,migration,andinvasion.
Description
HSPA5MouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining659aminoacids(20-655a.a)andhavingamolecularmassof72.9kDa.HSPA5isfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
HSPA5proteinsolution(0.5mg/ml)containingPhosphatebufferedsaline(pH7.4)and10%Glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSGGPPPTGEEDTSEKDEL
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.