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Other_recombinant_protein >
Prospec/FABP4 Human/Fatty Acid Binding Protein 4 Human/100µg/PRO-1568-100µg-100µg
Cataloguenumber
PRO-1568
Synonyms
Introduction
AdipocytefattyacidbindingproteinFABP4isa15kDamemberoftheintracellularfattyacidbindingprotein(FABP)family,whichisknownfortheABIlitytobindfattyacidsandrelatedcompounds(bileacidsorretinoids)inaninternalcavity.FABP4isexpressedinadifferentiation-dependentfashioninadipocytesandisacriticalgeneintheregulationoftheBIOLOGicalfunctionofthesecells.Inmice,targetedmutationsinFABP4providesignificantprotectionfromIRinthecontextofbothdietaryandgeneticobesity.AdipocytesobtainedfromFABP4-deficientmicealsohavereducedefficiencyofipolysisinvitroandinvivo,andthesemiceexhibitedmoderatelyimprovedsystemicdyslipidemia.RecentstudiesalsodemonstratedFABP4expressioninmacrophagesupondifferentiationandactivation.Inthesecells,FABP4modulatesinflammatoryresponsesandcholesterolesteraccumulation,andtotalormacrophage-specificFABP4deficiencyconfersdramaticprotectionagainstatherosclerosisintheapoE-/-mice.TheseresultsindicateacentralroleforFABP4inthedevelopmentofmajorcomponentsofthemetabolicsyndromethroughitsdistinctactionsinadipocytesandmacrophages.
Description
Source
PhysicalAppearance
Formulation
Solubility
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Aminoacidsequence
SafetyDataSheet
SDS