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Prospec/EIF4EBP1 Human/Eukaryotic translation initiation factor 4E-binding protein 1 Human Recombinant/10µg/PRO-532-10µg-10µg
Cataloguenumber
PRO-532
Synonyms
Eukaryotictranslationinitiationfactor4E-bindingprotein1,eIF4E-bindingprotein1,4E-BP1,PHAS-I,EIF4EBP1,BP-1,4EBP1,MGC4316.
Introduction
EIF4EBP1(eukaryotictranslationinitiationfactor4E-bindingprotein1)belongstoafamilyoftranslationrepressorproteins.EIF4EBP1regulateseIF4E(eukaryotictranslationinitiationfactor4E)activitybypreventingitsassemblyintotheeIF4Fcomplexandmediatestheregulationofproteintranslationbyhormones,growthfactorsandotherstimulithatsignalthroughtheMAPkinaseandmTORC1pathways.EIF4EBP1isphosphorylatedinresponsetovarioussignalsincludingUVirrADIation,resultinginitsdissociationfromeIF4EandactivationofmRNAtranslation.EIF4EBP1C-terminushasdomainswhichcontrolfunctionandphosphorylation.EIF4EBP1hasaroleinprogressionofbreastneoplasmsthroughcellsignaling.
Description
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