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Prospec/EDAR Human, Sf9/Ectodysplasin A Receptor Human Recombinant, Sf9/1mg/PRO-2510-1mg-1mg
Cataloguenumber
PRO-2510
Synonyms
EctodysplasinAReceptor,Ectodysplasin1,AnhidroticReceptor,AnhidroticEctodysplasinReceptor1,EctodermalDysplasiaReceptor,DownlessHomolog,EDA-A1Receptor,DL,TumorNecrosisFactorReceptorSuperfamilyMemberEDAR,Downless,Mouse,HomologOf,Ectodysplasin-AReceptor,ECTD10A,ECTD10B,EDA-A1R,EDA1R,ED1R,EDA3,HRM1,ED5,ED3.
Introduction
EctodysplasinAReceptor,alsoknownasEDARbelongstothetumornecrosisfactorreceptorfamily.EDARisareceptorforthesolubleligandectodysplasinA,andiscapableofactivatingthenuclearfactor-kappaB,JNK,aswellascaspase-independentcelldeathpathways.EDARisnecessaryforthedevelopmentofhair,teeth,andotherectodermalderivatives.FurThermore,mutationsinEDARresultedinautosomaldominantandrecessiveformsofhypohidroticectodermaldysplasia.
Description
EDARproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining413aminoacids(27-187a.a.)andhavingamolecularmassof45.6kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately40-57kDa).EDARisexpressedwitha249aminoacidhIgG-His-tagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
EDARproteinsolution(0.5mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATAAAAFESACSLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS
