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Prospec/Cystatin-C Protein/Cystatin-C Human Recombinant/50µg/PRO-2601-50µg-50µg

Cataloguenumber
PRO-2601
Synonyms
Cystatin-C,Cystatin-3,Neuroendocrinebasicpolypeptide,Gamma-trace,Post-gamma-globulin,CST3,MGC117328.
Introduction
Cystatinsareasuperfamilyofcysteineproteinaseinhibitorsfoundinbothplantsandanimals.Theycompriseagroupofproteinaseinhibitors,widelydistributedintissuesandbodyfluids,andformtightcomplexeswithcysteineproteasessuchascathepsinB,H,LandS.CystatinC,asecretedmoleculeofthisfamily,isofinterestfrombiochemical,medicineandevolutionarypointsofview.CystatinCisincreasedinpatientswithmalignantdiseases,andisrelatedtotheinsufficiencyofrenalfunctionandappearstobeabetterMarkerthancreatinine.Ontheotherhand,lowlevelsofcystatinCinvolvecausethebreakdownoftheelasticlaminaeandsubsequently,theatherosclerosisandaBDominalaorticaneurysm.
Description
Cystatin-CHumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining120aminoacidsandhavingamolecularmassof13.3kDa.Cystatin-Cispurifiedbyproprietarychromatographictechniques.
Source
EscherichiaColi.
PhysicalAppearance
Formulation
Cystatin-Cissuppliedasa0.2μmfilteredsolutionconteining20mMTris-HCl,50%glycerol,pH8.0and300mMNaCl.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan98.0%asdeterminedby:(a)AnalysisbyRP-HPLC.(b)AnalysisbySDS-PAGE.
Aminoacidsequence
SSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA.
SafetyDataSheet
SDS