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Prospec/CLEC5A Human, Sf9/C-Type Lectin Domain Family 5, Member A Human Recombinant, Sf9/5µg/PRO-2554-5µg-5µg

Cataloguenumber
PRO-2554
Synonyms
Introduction
C-typelectindomainfamily5-memberAisoform1(CLEC5A)ispartoftheCTL/CTLDsuperfamilywhichcarryvariousfunctions,forinstancecell-cellsignaling,celladhesion,glycoproteinturnover,inadditiontotheirinflammation&immuneresponseABIlities.CLEC5Aoperatesasacellattachmentreceptorforall4SEROtypesofDenguevirusinadditiontoJapaneseencephalitisvirus.CLEC5AbindstothedenguevirusandittriggerssignalingthroughthephosphylationofTYROBP,asaresultnoviralentranceoccurs,howeverthisinteractiondoesstimulateproinflammatorycytokinerelease.CLEC5Apreformsasapositiveregulatorofosteoclastogenesisandalsoamainregulatorofsynovialinjury&boneerosionfortheperiodofautoimmunejointinflammation.
Description
CLEC5AproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(28-188a.a.)andfusedtoa9aaHisTagatC-terminuscontainingatotalof170aminoacidsandhavingamolecularmassof19.5kDa.CLEC5Ashowsmultiplebandsbetween28-40kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
CLEC5Aproteinsolution(0.25mg/ml)contains20%glycerol,1mMDTT&Phosphatebufferedsaline(pH7.4).
Stability
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGNVTNQNQNFNCATIGLTKTFDAASCDISYRRICEKNAKHHHHHH
SafetyDataSheet
SDS